Symptom Relief Cough Suppressants a. Narcotic cough suppressants are the most potent which are thought to act in the “cough center” in the brainstem. The tendency of narcotic cough suppressants to cause drowsiness and constipation and their potential for addictive dependence limit their appeal for long-term use. Codeine: 7.5 mg to 30 mg every 4-6 hours as needed.1 Hydrocodone: 5 mg taken every 4-6 hours as needed.1 Maximum daily dose should not exceed 30 mg (6 tablets or 6 teaspoons of syrup) in 24 hours b. Dextromethorphan is an over-the-counter, centrally acting cough suppressant with fewer side effects and less efficacy than the narcotic cough suppressants. Dextromethorphan is thought to have a different site of action than narcotic cough suppressants and can be used in combination with them if necessary. Adult Dosage Immediate-release formulations: 10 to 20 mg orally every 4 hours, or 30 mg orally every 6 to 8 hours Extended-release formulations: 60 mg orally every 12 hours The maximum adult dose is 120 mg in 24 hours .2 Research Frontier Novel cough suppressants without the limitations of currently available agents are greatly needed. Approaches that are being explored include the development of neurokinin receptor antagonists, TRPV1 ion channel antagonists, and novel opioid and opioid-like receptor agonists.1 References 1. https://reference.medscape.com/drug/codeine-343310 <a href="#top">Back to top</a>
Cough Suppressants a. Narcotic cough suppressants are the most potent which are thought to act in the “cough center” in the brainstem. The tendency of narcotic cough suppressants to cause drowsiness and constipation and their potential for addictive dependence limit their appeal for long-term use. Codeine: 7.5 mg to 30 mg every 4-6 hours as needed.1 Hydrocodone: 5 mg taken every 4-6 hours as needed.1 Maximum daily dose should not exceed 30 mg (6 tablets or 6 teaspoons of syrup) in 24 hours b. Dextromethorphan is an over-the-counter, centrally acting cough suppressant with fewer side effects and less efficacy than the narcotic cough suppressants. Dextromethorphan is thought to have a different site of action than narcotic cough suppressants and can be used in combination with them if necessary. Adult Dosage Immediate-release formulations: 10 to 20 mg orally every 4 hours, or 30 mg orally every 6 to 8 hours Extended-release formulations: 60 mg orally every 12 hours The maximum adult dose is 120 mg in 24 hours .2 Research Frontier Novel cough suppressants without the limitations of currently available agents are greatly needed. Approaches that are being explored include the development of neurokinin receptor antagonists, TRPV1 ion channel antagonists, and novel opioid and opioid-like receptor agonists.1 References 1. https://reference.medscape.com/drug/codeine-343310 <a href="#top">Back to top</a>
Cough Suppressants
a. Narcotic cough suppressants are the most potent which are thought to act in the “cough center” in the brainstem. The tendency of narcotic cough suppressants to cause drowsiness and constipation and their potential for addictive dependence limit their appeal for long-term use. Codeine: 7.5 mg to 30 mg every 4-6 hours as needed.1 Hydrocodone: 5 mg taken every 4-6 hours as needed.1 Maximum daily dose should not exceed 30 mg (6 tablets or 6 teaspoons of syrup) in 24 hours b. Dextromethorphan is an over-the-counter, centrally acting cough suppressant with fewer side effects and less efficacy than the narcotic cough suppressants. Dextromethorphan is thought to have a different site of action than narcotic cough suppressants and can be used in combination with them if necessary. Adult Dosage Immediate-release formulations: 10 to 20 mg orally every 4 hours, or 30 mg orally every 6 to 8 hours Extended-release formulations: 60 mg orally every 12 hours The maximum adult dose is 120 mg in 24 hours .2
a. Narcotic cough suppressants are the most potent which are thought to act in the “cough center” in the brainstem. The tendency of narcotic cough suppressants to cause drowsiness and constipation and their potential for addictive dependence limit their appeal for long-term use.
Codeine: 7.5 mg to 30 mg every 4-6 hours as needed.1 Hydrocodone: 5 mg taken every 4-6 hours as needed.1 Maximum daily dose should not exceed 30 mg (6 tablets or 6 teaspoons of syrup) in 24 hours
Codeine: 7.5 mg to 30 mg every 4-6 hours as needed.1
Hydrocodone: 5 mg taken every 4-6 hours as needed.1
b. Dextromethorphan is an over-the-counter, centrally acting cough suppressant with fewer side effects and less efficacy than the narcotic cough suppressants. Dextromethorphan is thought to have a different site of action than narcotic cough suppressants and can be used in combination with them if necessary.
Adult Dosage
Research Frontier
Novel cough suppressants without the limitations of currently available agents are greatly needed. Approaches that are being explored include the development of neurokinin receptor antagonists, TRPV1 ion channel antagonists, and novel opioid and opioid-like receptor agonists.1
References
1. https://reference.medscape.com/drug/codeine-343310 <a href="#top">Back to top</a>