Nodular glomerulosclerosis refers to scarring of the tiny filtering units inside the kidneys, known as glomeruli. These glomeruli play a crucial role in filtering waste products and excess fluid from the blood. When they become scarred, protein leaks into the urine, leading to a condition called proteinuria. Here are some key points about nodular glomerulosclerosis:
Causes: Glomerulosclerosis can result from various factors, including infections, certain medications, diabetes, sickle cell disease, lupus, or other glomerular diseases.
Symptoms: Early stages may be asymptomatic, but proteinuria is a significant sign.
Diagnosis: Blood and urine tests can often detect glomerulosclerosis. A kidney biopsy may be necessary for confirmation.
Treatment: While scarred glomeruli cannot be repaired, treatment aims to prevent further damage. Options include immune system medicines, dialysis, kidney transplant, blood pressure management, and dietary changes1.
In the context of diabetic nephropathy, nodular sclerosis represents advanced scar tissue formation in the mesangium, forming larger nodules known as Kimmelstiel-Wilson lesions. These occur in later stages of diabetic nephropathy23. If you have any concerns or experience worsening symptoms, please consult your healthcare provider promptly. 🌟