Significant alcohol consumption is consumption of >210 grams of alcohol per week in men (14 drinks) or >140 grams of alcohol per week in women (10 drinks) over at least a two-year period, a definition that is consistent with a 2012 joint guideline from the American Gastroenterological Association, the American Association for the Study of Liver Diseases, and the American College of Gastroenterology [14]. A standard drink (360 mL [12 oz] of beer, 150 mL [5 oz] of wine, or 45 mL [1.5 oz] of 80-proof spirits) contains approximately 14 grams of alcohol.










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