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Many patients with HUS develop oligo-anuric renal failure, CNS involvement, and require renal replacement therapy (RRT). Close to one-third of patients who recover will have ongoing chronic kidney disease as a result of HUS. Intravenous fluids are used conservatively due to concern for volume overload during the oligo-anuric phase. The current study sought to evaluate the effects of clinical hypovolemia and intravenous fluid therapy during the initial presentation of STEC and the risk of HUS and its consequences.



    HUS is the most common cause of acute kidney injury in children and is increasingly recognized in adults. [1234].


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Damage to endothelial cells is the primary event in the pathogenesis of hemolytic-uremic syndrome (HUS). The cardinal lesion is composed of arteriolar and capillary microthrombi (thrombotic microangiopathy [TMA]) and red blood cell (RBC) fragmentation.

HUS is classified into two main categories, depending on whether it is associated with Shiga-like toxin (Stx) or not. [910] Shiga-like toxin is so called because it was initially identified in studies of Shigella dysenteriae, but this toxin is also elaborated by Escherichia coli.

A group of teenagers became ill with nausea, vomiting, severe abdominal cramps, and diarrhea after eating undercooked hamburgers from a local restaurant. Two of the teenagers were hospitalized with hemolytic-uremic syndrome. E. coli O157:H7 was isolated from the patient’s stools as well as from uncooked hamburgers. The O157 refers to which bacterial structure?

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Diseases and Disorders

Digital World Medical School
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Update January 7, 2020