Significant alcohol consumption is consumption of >210 grams of alcohol per week in men (14 drinks) or >140 grams of alcohol per week in women (10 drinks) over at least a two-year period, a definition that is consistent with a 2012 joint guideline from the American Gastroenterological Association, the American Association for the Study of Liver Diseases, and the American College of Gastroenterology [14]. A standard drink (360 mL [12 oz] of beer, 150 mL [5 oz] of wine, or 45 mL [1.5 oz] of 80-proof spirits) contains approximately 14 grams of alcohol.

 

 

 

 

 

 

 

 

 

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 A 35-year-old man with a known history of severe chronic alcohol abuse presents with low-grade fever, jaundice, hepatomegaly, leukocytosis, and markedly abnormal liver function tests. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are both elevated. An expected histologic finding in this condition is

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    A. effacement of the normal liver architecture by diffuse fibrosis and abnormal regenerating nodules.

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    B. Mallory hyaline inclusions, macrovesicular steatosis, and neutrophilic infiltration.

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    C. multiple giant cells.

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    D. nests or cords of well-differentiated cells separated by dense collagen lamellae.

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    E. parenchymal deposition of hemosiderin.

    Answer

 


 

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