Significant alcohol consumption is consumption of >210 grams of alcohol per week in men (14 drinks) or >140 grams of alcohol per week in women (10 drinks) over at least a two-year period, a definition that is consistent with a 2012 joint guideline from the American Gastroenterological Association, the American Association for the Study of Liver Diseases, and the American College of Gastroenterology [14]. A standard drink (360 mL [12 oz] of beer, 150 mL [5 oz] of wine, or 45 mL [1.5 oz] of 80-proof spirits) contains approximately 14 grams of alcohol.










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 A 35-year-old man with a known history of severe chronic alcohol abuse presents with low-grade fever, jaundice, hepatomegaly, leukocytosis, and markedly abnormal liver function tests. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are both elevated. An expected histologic finding in this condition is


    A. effacement of the normal liver architecture by diffuse fibrosis and abnormal regenerating nodules.


    B. Mallory hyaline inclusions, macrovesicular steatosis, and neutrophilic infiltration.


    C. multiple giant cells.


    D. nests or cords of well-differentiated cells separated by dense collagen lamellae.


    E. parenchymal deposition of hemosiderin.




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