Paget disease of bone (PDB), also known historically as osteitis deformans, is a focal disorder of bone metabolism that occurs in the aging skeleton.

It is characterized by an accelerated rate of bone remodeling, resulting in overgrowth of bone at single (monostotic PDB) or multiple (polyostotic PDB) sites and impaired integrity of affected bone.

Commonly affected areas include the skull, spine, pelvis, and long bones of the lower extremity.


Baseline radionuclide bone scan to document the extent and locations of skeletal involvement;

we perform radiographs of affected sites to identify impending fractures, potential malignant lesions, osteoarthritis, or other bone abnormalities.

(See 'Diagnosis' above and 'Role of imaging' above and 'Role of biochemical studies' above.)




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