A 30-year-old African-American woman presents with bilateral hilar lymphadenopathy and reticular densities in both lung fields. Which of the following is a defining characteristic of the disorder suggested by these findings?
A. Abnormalities restricted to lung and hilar lymph nodes
B. Hypocalcemia
C. Impaired synthesis of immunoglobulins
D. Marked hyperreactivity to tuberculin
E. Noncaseating granulomas
Answer
A 28-year-old woman is found to have pulmonary sarcoidosis. Flow cytometric analysis of T cells isolated from the alveoli and lung interstitium reveals the presence of large numbers of T helper (TH1) cells. These cells are known to secrete which of the following substances?
A. Complement component C5A
B. Elastase and lysyl hydroxylase
C. IL-2 and interferon-γ
D. IL-8 and transforming growth factor β
E. Leukotrienes C4 and C5
Answer
Content 3