Pharmacokinetics: absorption, distribution, metabolism, excretion, dosage intervals

Mechanisms of drug action, structure-activity relationships (eg, anticancer drugs)

Pharmacodynamics: Concentration and dose-effect relationships (eg, efficacy, potency), types of agonists (eg, full, partial, inverse) and antagonists and their actions

Individual factors altering pharmacokinetics and pharmacodynamics (eg, age, gender, disease, tolerance, compliance, body weight, metabolic proficiency, pharmacogenetics)

Mechanisms of drug adverse effects, overdosage, toxicology

Mechanisms of drug interactions

Signal transduction, including structure/function of all components of signal transduction pathways such as receptors, ligands (eg, general principles of nitric oxide, autocrine and paracrine signaling)